HCID 19787969, compound → HCID 19787965, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.0 g of 6-benzyloxy-3-formyl-4-methoxymethyl -9-(4-methylphenylsulfonyl)-beta-carboline in 60 ml of absolute tetrahydrofuran was mixed at -60° C. under argon with 2.4 ml of a 1.08 molar phenyllithium solution in ether/hexane, stirred for 1 hour at -60° C. and then heated slowly to room temperature. After taking up in ethyl acetate/water, the organic phase was separated, washed with saturated sodium chloride solution, dried and concentrated by evaporation. After column chromatography on silica gel with the eluants dichloromethane/ethanol 15:1 and cyclohexane/ethyl acetate 1:1, 717 mg of the title compound was obtained with melting point 169°-171° C.

Provenance & Evidence