HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorophenol → HCID 67883721, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorophenol | HCID 7245 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 1H-indol-4-ylmethanol | HCID 2773457 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67883721 | HCID 67883721 | — |
Reaction Steps
A solution of 4-hydroxymethylindole (1.0 g) in tetrahydrofuran (10 ml) is instilled in a solution of triphenylphosphine (2.92 g), 2-chlorophenol (1.43 g) and azodicarboxylic acid diethyl ester (1.49 g) in tetrahydrofuran (50 ml). After a three-hour stirring of the reaction mixture, it is worked up in the usual way and the crude product is chromatographed, melting point 138°-140° C. (cyclohexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05254563 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-545968b7949c42598eabd8bcbd084055 |
| Source note | uspto-grants-1993_10 |