Ammonia → HCID 18404757, compound

HRID 1656397Notes

Reaction equation

HRID 1656397 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])[NH:5][C:4](=[O:18])[C:3]=1[C:19]([O:21]C)=O.[NH3:23]>>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])[NH:5][C:4](=[O:18])[C:3]=1[C:19]([NH2:23])=[O:21]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 19788061HCID 19788061, compound

Product 1

HCID 18404757HCID 18404757, compound

Procedure

Methyl 1,2-dihydro-4-methyl-2-oxo-6-(2-propoxyphenyl)-pyridine-3-carboxylate (0.53 g) and saturated methanolic ammonia (25 ml) was heated in a sealed vessel at 70°-85° C. for 34 hours. The residue after evaporation was triturated with methanol (10 ml) to give a solid, 0.28 g, m.p. 239°-242° C. Recrystallisation from ethanol afforded the title compound, 0.18 g , m.p. 244°-246° C.

Workup

  1. customThe residue after evaporation
  2. customwas triturated with methanol (10 ml)
  3. customto give a solid, 0.28 g, m.p. 239°-242° C
  4. customRecrystallisation from ethanol

Sources & evidence

ORD record
ord-4356e4b892984a14bac27254b751f0cd
Source dataset
uspto-grants-1993_10
Patent number
US05254571

Reaction notes

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