Potassium Carbonate → HCID 19787719, compound

Participants

Reaction Steps

A suspension of 4-(naphth-1-yl)-2-n-propylimidazole-5-carboxaldehyde (0.90 g, 39.7 mmol, 1 eq), 4-bromomethyl-2'-(N-triphenylmethyl-(1H-tetrazol-5-yl))biphenyl (2.03 g, 43.7 mmol), 1.1 eq), dry DMF (20 mL), and 3.0 g of potassium carbonate was stirred at room temperature for 18 h. The reaction mixture was filtered, the precipitate was washed with methylene chloride and evaporated under reduced pressure. The residue was chromatographed in 98:2 methylene chloride/ethyl acetate over silica gel to yield a yellow foam. Yield: 1.50 g. NMR (CDCl3) δ 9.45 (s, 1H); 7.85 (m, 1H); 6.86-7.45 (m, 29H); 5.55 (s, 2H); 2.60 (t, 2H); 1.80 (m, 2H); 0.95 (t, 3H). ##STR78##

Provenance & Evidence