2,4-Difluorophenyl isocyanate → HCID 15035135, compound

Participants

Reaction Steps

A mixture of 6-chloro-3-methylamino-4-phenylquinoline (0.54 g), 2,4-difluorophenyl isocyanate (0.48 ml) and anhydrous toluene (10 ml) was refluxed for 22 hrs. and then concentrated. The residue was purified by a column chromatography on silica gel and recrystallized from a mixture of ethyl acetate and ethanol to give 6-chloro-3-[3-(2,4-difluorophenyl)-1-methylureido]-4-phenylquinoline as colorless crystals. Yield 0.56 g (66%). m.p. 200°-201° C.

Provenance & Evidence