m-Chloroperbenzoic acid → HCID 15035153, compound

Participants

Reaction Steps

A mixture of 4-(2-chlorophenyl)-3-[3-(2,4-difluoro-phenyl)ureido]- 6,8-dimethylquinoline (1.1 g), m-chloroperbenzoic acid (1.08 g) and dichloromethane (15 ml) was refluxed for 20 hrs. The reaction mixture was washed with aqueous sodium sulfite solution, aqueous sodium hydrogen carbonate solution and water, successively. After being dried over anhydrous magnesium sulfate, the solvent was distilled off. The residue was recrystallized from a mixture of methanol and chloroform to give 4-(2-chlorophenyl)-3-[3-(2,4-difluorophenyl)ureido]-6,8-dimethylquinoline 1-oxide as pale yellow prisms. Yield 0.72 g (63.2%). m.p. 230°-232° C.

Provenance & Evidence