HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(2-Chlorophenyl)-6,8-dimethyl-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Methyl 4-(2-chlorophenyl)-6,8-dimethyl-3-quinolinecarboxylate | HCID 10245799 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-Chlorophenyl)-6,8-dimethyl-3-quinolinecarboxylic acid | HCID 9995624 | 96.8% |
Reaction Steps
A mixture of methyl 4-(2-chlorophenyl)-6,8-dimehtyl-3-quinolinecarboxylate (0.98 g), potassium hydroxide (0.5 g) and 80% ethanol (10 ml) was refluxed for 15 mins. The mixture was diluted with water and acidified with hydrochloric acid to give 4-(2-chlorophenyl)-6,8-dimethyl-3-quinolinecarboxylic acid as crystals (0.90 g, 96.8%), which was recrystallized from ethanol as colorless prisms. m.p. 234°-235° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05254565 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-1a36d8c5fb574b358e3ef3e97dc172ce |
| Source note | uspto-grants-1993_10 |