Sulfuric Acid → HCID 19788019, compound

Participants

Reaction Steps

A mixture of 2-tosylamino-5-chloro-2'-hydroxy-3', 4'-dimethoxybenzophenone (5.89 g) and 70% sulfuric acid (50 ml) was heated for 1 hr. at 90° C. The whole was diluted with water and extracted with chloroform. The chloroform layer was washed with water, dried over anhydrous magnesium sulfate and concentrated. The residue was purified by a column chromatography on silica gel and recrystallized from a mixture of ether and hexane to give 2-amino-5-chloro-2'-hydroxy-3',4'-dimethoxybenzophenone as colorless prisms (3.01 g, 76.8%). m.p. 112°-115° C.

Provenance & Evidence