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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1656450Generated: November 1, 2026

Sodium Hydroxide → N-[Hydroxy(5-sulfanyl-3,4-dihydro-2H-pyrrol-2-yl)methylidene]cysteine

https://huagongshe.com/reaction/1656450

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantLawesson's reagentHCID 87949—
ReactantHCID 22884206HCID 22884206—
ProductN-[Hydroxy(5-sulfanyl-3,4-dihydro-2H-pyrrol-2-yl)methylidene]cysteineHCID 10220554—

Reaction Steps

Thionation of N-(5-oxo-L-prolyl)-L-cysteine methyl ester with the Lawesson's reagent and the subsequent alkali hydrolysis with two sodium hydroxide equivalents in aqueous solution yields N-(5-thioxo-L-prolyl)-L-cysteine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05254579
Source datasetuspto-grants-1993_10
ORD IDord-e21356afcaa548299cdfe4bb96e50da8
Source noteuspto-grants-1993_10