HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Chloro-5-formylbenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Chloro-5-forMylbenzoic Acid | HCID 19788166 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Chloro-5-formylbenzoyl chloride | HCID 19788154 | — |
Reaction Steps
A mixture of 3-formyl-5-chlorobenzoic acid (66.5 g, 0.36 moles), thionyl chloride (51.5 g, 0.43 moles), and dimethylformamide (1 ml), in toluene (400 ml) was slowly warmed to 70° C. and stirred at that temperature for 2 hours. The toluene was eliminated in the rotavap to yield 3-formyl-5-chlorobenzoyl chloride, used in the next step as such.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05254584 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-1f82e65021534d69b7528104fda61cc9 |
| Source note | uspto-grants-1993_10 |