HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Formyl-5-methylbenzoic chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Formyl-5-methylbenzoic acid | HCID 19788173 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Formyl-5-methylbenzoic chloride | HCID 19788156 | — |
Reaction Steps
A mixture of 3-formyl-5-methylbenzoic acid (75.0 g, 0.457 moles), thionyl chloride (65 g, 0.0547 moles), and dimethylformamide (1 ml), in toluene (500 ml) was slowly warmed to 70° C. and stirred at that temperature for 2 h. The toluene was eliminated in a rotavap to yield 3-formyl-5-methylbenzoic chloride used in the next step as such.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05254584 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-6d3c04233a8e4a55bde39445076d3e8c |
| Source note | uspto-grants-1993_10 |