HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1656486Generated: October 31, 2026
Dimethylformamide → 3,5-Dichloro-4-formylbenzoyl chloride
https://huagongshe.com/reaction/1656486
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,5-dichloro-4-formylbenzoic acid | HCID 19788159 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3,5-Dichloro-4-formylbenzoyl chloride | HCID 19788147 | 115.8% |
Reaction Steps
A mixture of 4-formyl-3,5-dichlorobenzoic acid (15.0 g, 0.06 moles), thionyl chloride (12.1 g, 0.107 moles), and dimethylformamide (5 ml) in toluene (100 ml) was slowly warmed to 70° C. and stirred at that temperature for 2 hours. The toluene was eliminated in the rotavap to yield 16.5 g of 4-formyl-3,5-dichlorobenzoyl chloride used in the next step as such.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05254584 |
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| Source dataset | uspto-grants-1993_10 |
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| ORD ID | ord-bdb321b1468e41af96217e976d46362c |
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| Source note | uspto-grants-1993_10 |
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