HCID 10330620, compound → HCID 10022483, compound

HRID 1656495Notes

Reaction equation

HRID 1656495 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[C:8](=[O:14])[CH:7]=[CH:6]2.[CH2:15]([C:17]1([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([OH:29])[CH:24]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)[CH3:16]>>[CH2:15]([C:17]1([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH2:2][C:3]3[CH:4]=[C:5]4[C:10](=[CH:11][CH:12]=3)[N:9]([CH3:13])[C:8](=[O:14])[CH:7]=[CH:6]4)[CH:24]=2)[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1)[CH3:16]

Participants

3

Reactant 2

HCID 10330620HCID 10330620, compoundHCID 151990656-(Bromomethyl)-1-methylquinolin-2(1H)-one

Product 1

HCID 10022483HCID 10022483, compoundYield 63%

Procedure

Using a similar procedure to that described in Example 14, 6-bromomethyl-1-methyl-1,2-dihydroquinolin-2-one was reacted with 4-ethyl-4-(3-hydroxyphenyl)tetrahydropyran to give 4-ethyl-4-[3-(1-methyl-2-oxo-1,2-dihydroquinolin-6-ylmethoxy)phenyl]tetrahydropyran in 63% yield, m.p. 139° C.

Sources & evidence

ORD record
ord-a1ec65e45b0a4b66ba927899e4e1a697
Source dataset
uspto-grants-1993_10
Patent number
US05254581

Reaction notes

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