HRID1656513

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(NC(=O)NCc2cccnc2)c1=O)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F

HCID19787868

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(NC(=O)NCc2cccnc2)c1=O)C(O)C(F)(F)F

HCID19787867

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

2-[6-Oxo-2-phenyl-5-[3-(3-pyridylmethyl)ureido]-1,6-dihydro-1-pyrimidinyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide was subjected to a method similar to that described in Example 2.d. Chromatography, with methanol:dichloromethane (5:95) as the eluent, gave 2-[6-oxo-2-phenyl-5-[3-(3-pyridyl)methylureido]-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide as a white solid; MS: m/z=533(M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d54c33e45fdb460ebd6210fb4cd28ad0
来源数据集: uspto-grants-1993_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05254558
来源说明: uspto-grants-1993_10

反应 SMILES

[O:1]=[C:2]1[N:7]([CH2:8][C:9]([NH:11][CH:12]([CH:26]([CH3:28])[CH3:27])[CH:13]([O:18][Si](C(C)(C)C)(C)C)[C:14]([F:17])([F:16])[F:15])=[O:10])[C:6]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[N:5][CH:4]=[C:3]1[NH:35][C:36]([NH:38][CH2:39][C:40]1[CH:41]=[N:42][CH:43]=[CH:44][CH:45]=1)=[O:37]>CO.ClCCl>[O:1]=[C:2]1[N:7]([CH2:8][C:9]([NH:11][CH:12]([CH:26]([CH3:28])[CH3:27])[CH:13]([OH:18])[C:14]([F:15])([F:17])[F:16])=[O:10])[C:6]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[N:5][CH:4]=[C:3]1[NH:35][C:36]([NH:38][CH2:39][C:40]1[CH:41]=[N:42][CH:43]=[CH:44][CH:45]=1)=[O:37]