HCID 19787868, compound → HCID 19787867, compound

HRID 1656513Notes

Reaction equation

HRID 1656513 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][C:9]([NH:11][CH:12]([CH:26]([CH3:28])[CH3:27])[CH:13]([O:18][Si](C(C)(C)C)(C)C)[C:14]([F:17])([F:16])[F:15])=[O:10])[C:6]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[N:5][CH:4]=[C:3]1[NH:35][C:36]([NH:38][CH2:39][C:40]1[CH:41]=[N:42][CH:43]=[CH:44][CH:45]=1)=[O:37]>CO.ClCCl>[O:1]=[C:2]1[N:7]([CH2:8][C:9]([NH:11][CH:12]([CH:26]([CH3:28])[CH3:27])[CH:13]([OH:18])[C:14]([F:15])([F:17])[F:16])=[O:10])[C:6]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[N:5][CH:4]=[C:3]1[NH:35][C:36]([NH:38][CH2:39][C:40]1[CH:41]=[N:42][CH:43]=[CH:44][CH:45]=1)=[O:37]

Participants

3

Reactant 1

HCID 19787868HCID 19787868, compound

Product 1

HCID 19787867HCID 19787867, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

2-[6-Oxo-2-phenyl-5-[3-(3-pyridylmethyl)ureido]-1,6-dihydro-1-pyrimidinyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide was subjected to a method similar to that described in Example 2.d. Chromatography, with methanol:dichloromethane (5:95) as the eluent, gave 2-[6-oxo-2-phenyl-5-[3-(3-pyridyl)methylureido]-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide as a white solid; MS: m/z=533(M+1).

Sources & evidence

ORD record
ord-d54c33e45fdb460ebd6210fb4cd28ad0
Source dataset
uspto-grants-1993_10
Patent number
US05254558

Reaction notes

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