HCID 19787871, compound → HCID 19787901, compound

HRID 1656514Notes

Reaction equation

HRID 1656514 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][C:9]([NH:11][CH:12]([CH:19]([CH3:21])[CH3:20])[CH:13]([OH:18])[C:14]([F:17])([F:16])[F:15])=[O:10])[C:6]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[N:5][CH:4]=[C:3]1[NH:28][C:29]([NH:31][CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1)=[O:30]>CO.ClCCl>[O:1]=[C:2]1[N:7]([CH2:8][C:9]([NH:11][CH:12]([CH:19]([CH3:21])[CH3:20])[C:13](=[O:18])[C:14]([F:15])([F:17])[F:16])=[O:10])[C:6]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[N:5][CH:4]=[C:3]1[NH:28][C:29]([NH:31][CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1)=[O:30]

Participants

3

Reactant 1

HCID 19787871HCID 19787871, compound

Product 1

HCID 19787901HCID 19787901, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

2-[6-Oxo-2-phenyl-5-[3-(4-pyridylmethyl)ureido]-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide was subjected to a procedure similar to that described in Example 1. Chromatography, with methanol:dichloromethane (10:90) as the eluent, gave 2-[6-oxo-2-phenyl-5-[3-(4-pyridylmethyl)ureido]-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide as a white solid; NMR (DMSO/D2O): 8.58 (s,1), 8.46 (bs, 2), 7.41 (m,5), 7.27 (d,2), 4.56 (d,1), 4.37 (d,1), 4.32 (s,2), 4.00 (d,1), 2.20 (m,1), 0.79 (d,3), 0.73 (d,3); MS: m/z=531(M+1).

Sources & evidence

ORD record
ord-08dbd1bb617d473eb9377bd7667e1611
Source dataset
uspto-grants-1993_10
Patent number
US05254558

Reaction notes

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