Methanol → HCID 10347501, compound

Participants

Reaction Steps

2-[2-(4-Fluoropheny)-6-oxo-5-(4-pyridylmethoxycarbonylamino)-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide was subjected to a procedure similar to that described in Example 1. Chromatography, with methanol:dichloromethane (gradient, 5:95, 7:93) as the eluent, gave 2-[2-(4-fluorophenyl)-6-oxo-5-(4-pyridylmethoxycarbonylamino)-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide as a white solid; NMR (DMSO/D2O): 8.54 (d,2), 8.44 (s,1), 7.53 (m,2), 7.44 (d,2), 7.22 (t,2), 5.22 (s,2), 4.70 (d,1), 4.49 (d,1), 4.01, (d,1), 2.20 (m,1), 0.85 (d,3), 0.72 (d,3).

Provenance & Evidence