3-Nitro-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine → 3-Amino-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine

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Reaction Steps

3-Nitro-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine (6.0 g, 0.017 mol) was dissolved in ethanol (50 mL) and catalytically reduced by hydrogen with Pd/C catalyst at room temperature for 2 hours. The mixture was filtered through filter-cel and the ethanol removed in vacuo to yield the pure product 3-amino-4-(2,4-bis(1,1-dimethylpropyl)phenoxy)-pyridine in 98% recovered yield. Mass spectral and NMR data were consistent with the proposed structure.

Provenance & Evidence