Ethanol → 2-Aminotetralin

HRID 1656615Notes

Reaction equation

HRID 1656615 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1C)=[C:8](OCC1OC1)[CH:7]=[CH:6][CH:5]=2.[CH2:17](O)C>Cl.C1C2C(=CC=CC=2)CCC1NCC(O)COC1C=CC=C2C=1C(C)=C(C)N2>[NH2:3][CH:2]1[CH2:1][CH2:17][C:8]2[C:9](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 702EthanolHCID 19788308HCID 19788308, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 14750955HCID 14750955, compoundSolvent

Procedure

Following the procedure described in Example 27, but starting from 2,3-dimethyl-4-(2,3-epoxypropoxy)indole (10 g) and 2-aminotetralin (6.9 g) in ethanol (100 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2,3-dimethylindol-4-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 14 wherein Z is methyl, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-cc4f3417359f43409bf7d11ccf2a83d9
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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