HCID 14750959, compound → 2-Aminotetralin

HRID 1656617Notes

Reaction equation

HRID 1656617 reaction equation
Cl.[CH2:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[NH:12]CC(O)COC1C=CC=C2C=1C=C(CC(OCC)=O)N2>C(O)C>[NH2:12][CH:3]1[CH2:4][CH2:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:2]1

Participants

3

Reactant 1

HCID 14750959HCID 14750959, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure described in Example 27, but starting from ethyl 4-(2,3-epoxypropoxy)indole-2-acetate (27.5 g), obtained from ethyl 4-hydroxyindole-2-acetate and epichlorohydrin according to the method of Swiss Patent 526,542, and 2-aminotetralin (14.8 g) in ethanol (120 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-ethoxycarbonylmethylindol-4-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 16 wherein Z is ethoxy, and the chain is attached to position 2 of the tetralin moiety) which is crystallized from a mixture ethanol/isopropanol 2/1.

Sources & evidence

ORD record
ord-ef6e70505e7444fdbe1a8a9509d6d6b1
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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