Ethanol → 2-Aminotetralin

HRID 1656619Notes

Reaction equation

HRID 1656619 reaction equation
O1CC1CO[C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[CH2:7][C:8](=O)[NH:9]2.[CH2:16](O)[CH3:17]>Cl.C1C2C(=CC=CC=2)CCC1NCC(O)COC1C=CC=C2C=1CC(=O)N2>[NH2:9][CH:8]1[CH2:17][CH2:16][C:5]2[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:7]1

Participants

4

Reactant 2

HCID 702EthanolHCID 13066242HCID 13066242, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 14750963HCID 14750963, compoundSolvent

Procedure

Following the procedure described in Example 27, but starting from 4-(2,3-epoxypropoxy)-2-oxoindoline (20.5 g) and 2-aminotetralin (14.81 g) in ethanol (150 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-oxo-2,3-dihydroindol-4-yloxy)propanamine hydrochloride is obtained, ((i): R=H, Ar=radical 18 wherein Z is H, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-1bd75b002ed64559bdd1121f2fe69250
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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