HCID 13064030, compound → 2-Aminotetralin

HRID 1656622Notes

Reaction equation

HRID 1656622 reaction equation
O1CC1CO[C:5]1[C:13]2[C:9](=NS[N:12]=2)[CH:8]=[CH:7][CH:6]=1>C(O)C.Cl.C1C2C(=CC=CC=2)CCC1NCC(O)COC1C2C(=NSN=2)C=CC=1>[NH2:12][CH:13]1[CH2:5][CH2:6][C:7]2[C:8](=[CH:13][CH:5]=[CH:6][CH:7]=2)[CH2:9]1

Participants

4

Reactant 1

HCID 13064030HCID 13064030, compound

Product 1

HCID 346772-AminotetralinYield 201.6%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14750975HCID 14750975, compoundSolvent

Procedure

Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)-2,1,3-benzothiadiazole (20.8 g), prepared according to the teaching of DE-2,404,858, and 2-aminotetralin (14.82 g) in absolute ethanol (125 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2,1,3-benzothiadiazol-4-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 32, and the chain is attached to position 2 of the tetralin moiety).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-fb161c0c871d43159a4cc8780163a8fb
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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