HCID 14750977, compound → 2-Aminotetralin

Participants

Reaction Steps

Following the procedure described in Example 27, but starting from 7-(2,3-epoxypropoxy)phtalide (20.6 g), obtained from 7-hydroxyphtalide and epichlorohydrin according to the teaching of Belgian Patent 815,745, and 2-aminotetralin (14.81 g) in absolute ethanol (125 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-phtalid-7-yloxypropanamine hydrochloride is obtained ((iF): L"=H, E" and G" taken together, form a group --CO--O--CH2 --, R=H, and the chain is attached to position 2 of the tetralin moiety).

Provenance & Evidence