Ethanol → 2-Aminotetralin

Participants

Reaction Steps

Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)-2-oxoindoline (20.3 g, see JP 49-094666) and 2-aminotetralin (14.81 g) in ethanol (100 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-oxoindolin-4-yloxy)-propanamine hydrochloride is obtained ((i): R=H, Ar=radical 36, and the chain is attached to position 2 of the tetralin moiety).

Provenance & Evidence