HCID 12541313, compound → 2-Aminotetralin

HRID 1656626Notes

Reaction equation

HRID 1656626 reaction equation
O1CC1COC1C=CC=C2C=1CCCC2=O.Cl.[CH2:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20][CH:19]1[NH:28]CC(O)COC1C=CC=C2C=1CCCC2=O>C(O)C>[NH2:28][CH:19]1[CH2:20][CH2:21][C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:18]1

Participants

4

Reactant 2

HCID 12541313HCID 12541313, compoundHCID 14750989HCID 14750989, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 27, but starting from 5-(2,3-epoxypropoxy)-1-oxotetralin (20.2 g), prepared as described in BE 739,195, and 2-aminotetralin (14.81 g) in absolute ethanol (130 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(1-oxo-1,2,3,4-tetrahydronaphth-5-yloxy)propanamine hydrochloride is obtained ((iA), R=H, E and G, taken together form a group --CH2 --CH2 --CH2 --CO--, and the chain is attached to position 2 of the tetralin moiety).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-0cc882f62f2b41929acedd620dfeff53
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

Loading…