HCID 14750993, compound → 2-Aminotetralin

HRID 1656628Notes

Reaction equation

HRID 1656628 reaction equation
O1CC1COC1C=CC=C2C=1OCC=C2.Cl.[CH2:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][CH2:19][CH:18]1[NH:27]CC(O)COC1C=CC=C2C=1OCC=C2>C(O)C>[NH2:27][CH:18]1[CH2:19][CH2:20][C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:17]1

Participants

4

Reactant 2

HCID 14750993HCID 14750993, compoundHCID 19788298HCID 19788298, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 27, but starting from 8-(2,3-epoxypropoxy)-2H-chromene (20.4 g) and 2-aminotetralin (14.85 g) in absolute ethanol (120 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2H-chromen-8-yloxy)-propanamine hydrochloride is obtained ((i): R=H, Ar=radical 44, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-5b64b04948104524b2bf1f78355c7355
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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