HCID 14750997, compound → 2-Aminotetralin

HRID 1656629Notes

Reaction equation

HRID 1656629 reaction equation
O1CC1COC1C=CC=C2C=1CCC2.Cl.[CH2:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19][CH2:18][CH:17]1[NH:26]CC(O)COC1C=CC=C2C=1CCC2>C(O)C>[NH2:26][CH:17]1[CH2:18][CH2:19][C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:16]1

Participants

4

Reactant 2

HCID 14750997HCID 14750997, compoundHCID 19788275HCID 19788275, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)indane (19 g) and 2-aminotetralin (14.81 g) in absolute ethanol (150 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-indan-4-yloxypropanamine hydrochloride is obtained ((iA): E and G, taken together, represent a group --CH2 --CH2 --CH2 --, R=H, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-f8149cbe366641759ac2bc1ff4665d39
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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