Ethanol → 2-Aminotetralin

HRID 1656631Notes

Reaction equation

HRID 1656631 reaction equation
C(O[C:4]([C:6]1[N:7]=NS[C:10]=1[C:11]1[CH:16]=[CH:15][C:14](OCC2OC2)=[CH:13][CH:12]=1)=O)C.[CH2:22](O)C>Cl.C1C2C(=CC=CC=2)CCC1NCC(O)COC1C=CC(C2SN=NC=2C(OCC)=O)=CC=1>[NH2:7][CH:6]1[CH2:4][CH2:22][C:12]2[C:11](=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 702EthanolHCID 19788318HCID 19788318, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 14751007HCID 14751007, compoundSolvent

Procedure

Following the procedure of Example 27, but starting from 4-(4-ethoxycarbonyl-1,2,3-thiadiazol-5-yl)-1-(2,3-epoxypropoxy)benzene (2.94 g) and 2-aminotetralin (1.49 g) in absolute ethanol (20 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-[4-(4-ethoxycarbonyl-1,2,3-thiadiazol-5-yl)phenoxy]propanamine hydrochloride is obtained ((i): R=H, Ar=radical 63, wherein Z is a 4-COOC2H5 group, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-414322dbf5984641a2ea827c63aeafa2
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

Loading…