Ethanol → 2-Aminotetralin

HRID 1656632Notes

Reaction equation

HRID 1656632 reaction equation
C([N:4]1[C:13]2[C:8](=[C:9](OCC3OC3)[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6][CH2:5]1)(=O)C.[CH2:19](O)C>Cl.C1C2C(=CC=CC=2)CCC1NCC(O)COC1C=CC=C2C=1CCCN2C(=O)C>[NH2:4][CH:5]1[CH2:6][CH2:7][C:8]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:19]1

Participants

4

Reactant 2

HCID 702EthanolHCID 19788355HCID 19788355, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 19788274HCID 19788274, compoundSolvent

Procedure

Following the procedure of Example 27, but starting from 1-acetyl-5-(2,3-epoxypropoxy)-1,2,3,4-tetrahydroquinoline (2.77 g) and 2-aminotetralin (1.49 g) in ethanol (30 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(1-acetyl-1,2,3,4-tetrahydroquinolin-5-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 66, wherein Z is methyl, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-544e3145d5f84447be20b9f3f6d8b044
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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