HCID 18621177, compound → 2-Aminotetralin

HRID 1656633Notes

Reaction equation

HRID 1656633 reaction equation
O1CC1CO[C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1C=N[NH:9]2>C(O)C.Cl.C1C2C(=CC=CC=2)CCC1NCC(O)CC1C=CC=C2C=1C=NN2>[NH2:9][CH:10]1[CH2:11][CH2:12][C:13]2[C:5](=[CH:13][CH:5]=[CH:6][CH:10]=2)[CH2:6]1

Participants

4

Reactant 1

HCID 18621177HCID 18621177, compound

Product 1

HCID 346772-AminotetralinYield 201.6%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 19788276HCID 19788276, compoundSolvent

Procedure

Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)indazole (1.91 g), prepared as described in BE 853,949, and 2-aminotetralin (1.49 g) in absolute ethanol (30 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-indazol-4-ylpropanamine hydrochloride is obtained ((i): R=H, Ar=radical 67, wherein Z= Z'=H, and the chain is attached to position 2 of the tetralin moiety).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-d7ca1d1b1a494da285acf18ab98c2b06
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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