HCID 9971103, compound → 2-Aminotetralin

HRID 1656634Notes

Reaction equation

HRID 1656634 reaction equation
O1CC1COC1C=C2C(=CC=1)C(=O)C1C(O)=CC=CC=1O2.Cl.[CH2:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25][CH:24]1[NH:33]CC(O)COC1C=C2C(=CC=1)C(=O)C1C(O)=CC=CC=1O2>C(O)C>[NH2:33][CH:24]1[CH2:25][CH2:26][C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:23]1

Participants

4

Reactant 2

HCID 9971103HCID 9971103, compoundHCID 19788345HCID 19788345, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 27, but starting from 6-(2,3-epoxypropoxy)-1-hydroxyxanthen-9-one (2.84 g), prepared as described in U.S. Pat. No. 3,912,733, and 2-aminotetralin (1.49 g) in absolute ethanol (40 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(1-hydroxy-9-oxoxanth-6-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 1, wherein Z is H, and the chain is attached to position 2 of the tetralin moiety).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-25de3471f1e549148ca4aa0925d21302
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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