Epichlorohydrin → 2-Aminotetralin

Participants

Reaction Steps

Following the procedure of Example 33, but starting from 7-hydroxy-3-methylthiophene and epichlorohydrin in the presence of sodium hydroxide and contacting a solution of the obtained raw epoxide in absolute ethanol with a solution of 2-aminotetralin in absolute ethanol, N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(3-methylbenzothien-7-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 28, wherein Z is methyl and the chain bridges position 7 of the Ar radical and position 2 of the tetralin moiety).

Provenance & Evidence