Potassium Carbonate → 2-Aminotetralin

Participants

Reaction Steps

Operating as described in Example 27, but starting from 8-acetylmethoxy-5-(2,3-epoxypropoxy)-3,4-dihydrocarbostyril, prepared by reacting 5,8-dihydroxy-3,4-dihydrocarbostyril with bromoacetone in the presence of potassium carbonate and in a mixture water/acetone 4/1, at the reflux temperature for 5 hours, and 2-aminotetralin (1.48 g) in absolute ethanol (30 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(8-acetylmethoxy-3,4-dihydrocarbostyril-5-yloxy)propanamine hydrochloride is obtained ((iF): R=H, L"=acetonyloxy, E" and G", taken together, represent a group --CH2 --CH2 --CO--NH--, and the chain is attached to position 2 of the tetralin moiety).

Provenance & Evidence