反应详情

A mixture of 1-(2-naphthyloxy)-2,3-epoxypropane (1.95 g), 2-aminotetralin (2.65 g) and ethanol (35 ml) is heated to the reflux temperature for 5 hours. The solvent is then evaporated off and the thus obtained solid residue is crystallized from ethyl acetate (5 ml), recovered by filtration, washed with ethyl acetate and then with ethyl ether, and dried yielding 1.8 g of N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-naphthyloxy)propanamine, as the free base; m.p. 102°-115° C.

1. temperatureis heated to the reflux temperature for 5 hours
2. customThe solvent is then evaporated off
3. customthe thus obtained solid residue is crystallized from ethyl acetate (5 ml)
4. filtrationrecovered by filtration
5. washwashed with ethyl acetate
6. dry with materialwith ethyl ether, and dried