反应详情

A solution of 1-(2-chlorophenoxy)-2,3-epoxypropane (2.65 g) prepared by the method described in British Patent 767,991, and 2-aminotetralin (2.1 g) in ethanol (70 ml) is heated to the reflux temperature for 5 hours. Ethanol is then evaporated off and the thus obtained residue is chromatographed on a silica gel column eluting with ethyl acetate. The residue which is obtained upon evaporation to dryness of the combined fractions is crystallized from ethyl acetate (10 ml) yielding 1.5 g of N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-chlorophenoxy)propanamine; m.p. 98°-101° C.

1. temperatureis heated to the reflux temperature for 5 hours
2. customEthanol is then evaporated off
3. customthe thus obtained residue is chromatographed on a silica gel column
4. washeluting with ethyl acetate
5. customThe residue which is obtained upon evaporation to dryness of the combined fractions
6. customis crystallized from ethyl acetate (10 ml)