7-Hydroxymethyl-2-phenyl-benzoxazole → 2-Phenylbenzo[d]oxazole-7-carbaldehyde

HRID 1656683Notes

Reaction equation

HRID 1656683 reaction equation
[OH:1][CH2:2][C:3]1[C:11]2[O:10][C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1>CC(C)=O.O=[Mn]=O>[C:12]1([C:9]2[O:10][C:11]3[C:3]([CH:2]=[O:1])=[CH:4][CH:5]=[CH:6][C:7]=3[N:8]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 199399197-Hydroxymethyl-2-phenyl-benzoxazole

Product 1

HCID 199399162-Phenylbenzo[d]oxazole-7-carbaldehyde

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 180AcetoneSolvent

Procedure

10 mmol of the compound from Example XVI were boiled under reflux with 50 mmol of MnO2 (active) in 50 ml of acetone for 6 h, the solid was filtered off with suction and the filtrate was concentrated. The residue was recrystallized from isopropanol. M.p.: 107° C.

Workup

  1. filtrationthe solid was filtered off with suction
  2. concentrationthe filtrate was concentrated
  3. customThe residue was recrystallized from isopropanol

Sources & evidence

ORD record
ord-443760b4694b4f3a97865e00e8cf48a7
Source dataset
uspto-grants-1993_10
Patent number
US05254692

Reaction notes

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