2-Chloroethanol → HCID 18953229, compound

Participants

Reaction Steps

2-Chloroethyl 2-hydroxy-2-methylpropionate was prepared from 2-hydroxy-2-methylpropionic acid and excess 2-chloroethanol essentially by the method described in Step 1 of Example 1: b.p. 75°-77° C./6 mm Hg; 1H NMR δ 1.47 (s, 6H), δ 3.18 (s, 1H), δ 3.72 (t, 2H, J=5.6 Hz), δ 4.43 (t, 2H, J=5.6 Hz); 13C NMR 27.1, 41.2, 64.8, 72.1, 176.8 ppm; HRMS calcd for C5H7ClO3Tms (M--CH3) 223.0557, obsd 223.0577.

Provenance & Evidence