Tert-Butylbenzene → HCID 53924236, compound

Participants

Reaction Steps

A 6 mL aliquot of an ethyl ether solution containing 0.25 M 2-chloroethyl 2-hydroxybutyrate, 0.25 M methyl glycolate, and 0.125% tert-butylbenzene was added to 0.43 g Lipase AK. After mixing for 48 hr at room temperature, the conversion of 2-chloroethyl 2-hydroxybutyrate to the title compound was estimated (by GC, Method A) to be 43%. The GC peak assigned to the title compound was confirmed by HRMS: calcd for C6H8O5TMS (M--CH3) 233.0845, obsd 233.0878. In identical reactions substituting Lipase P30, Lipase G, or porcine pancreatic lipase for Lipase AK, the relative values for conversions at 48 hr (Lipase AK=100) were 81, 71, and 48, respectively.

Provenance & Evidence