Tetrahydrofuran → HCID 20083184, compound

Participants

Reaction Steps

424 mg of the compound (170) obtained in Example 47, 404 mg of 3-tributylstanyl-2-cyclohexen-1-one, 127 mg of lithium chloride and 14 mg of bis(triphenylphosphine)palladium (11) chloride were added to 5 ml of tetrahydrofuran, and the solution was heated at reflux for three days under nitrogen. The solvent was removed by distillation. To the residue, n-hexane was added, and the solid matter was filtered off. The obtained solid matter was separated by column chromatography (silica gel, eluent solvent; chloroform:ethyl acetate=8:1) to obtain 120 mg of the subject compound (171).

Provenance & Evidence