Formaldehyde → HCID 20083158, compound

HRID 1656766Notes

Reaction equation

HRID 1656766 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][NH:6]3.[CH2:22]=[O:23]>C(O)(=O)C>[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][OH:23]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 20083163HCID 20083163, compound

Product 1

HCID 20083158HCID 20083158, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

100 mg of the compound (5) obtained in Example 1 was dissolved in 3 ml of acetic acid, and while stirring, 1.5 ml of formalin was added to the solution. The solution was stirred for 30 minutes, and the deposited solid matter was filtered off and washed with ether to obtain 64 mg of the subject compound (177).

Workup

  1. stirringThe solution was stirred for 30 minutes
  2. filtrationthe deposited solid matter was filtered off
  3. washwashed with ether

Sources & evidence

ORD record
ord-e15cd84d768541fe8ef02047918bb327
Source dataset
uspto-grants-1993_10
Patent number
US05254685

Reaction notes

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