Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | HCID 21733330 | HCID 21733330 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 19788687 | HCID 19788687 | 57.7% |
Reaction Steps
50 mg of compound (182) obtained in Example 59, 26 mg of pyrrolidine and 10 mg of triethylamine were added to 3 ml of acetonitrile, and the solution was heated at 80° C. for 3 hours. The solvent was removed by distillation. To the residue, ethanol was added, and the solid matter was filtered off and washed with ethanol and ether in this order to obtain 33 mg of the subject compound (183).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05254685 |
|---|
| Source dataset | uspto-grants-1993_10 |
|---|
| ORD ID | ord-80e016570a69484c8ec257b3d3a1b809 |
|---|
| Source note | uspto-grants-1993_10 |
|---|
