Acetic Acid → HCID 20083176, compound

Participants

Reaction Steps

To 40 mg (0.14 mmol) of the compound (190) obtained in Example 63, 0.3 ml of concentrated hydrochloric acid and 1.2 ml of acetic acid were added, and the solution was heated at reflux for 3 hours. After air-cooling, 5 ml of water was added to the solution, and deposited crystals were filtered off and washed with water, ethanol and ether in this order to obtain 30 mg of the subject compound (191) in a 79% yield.

Provenance & Evidence