1-Dodecanol → Dodecyl(chlorosulfonyl)carbamate

Participants

Reaction Steps

A solution of n-dodecyl alcohol (107 g, 52.4 mmoles) in 100 mL Et2O was added dropwise to a solution of chlorosulfonyl isocyanate (5.0 mL, 57.4 mmoles) in 100 mL Et2O at -15° C. under an atmosphere of N2. The resulting mixture was stirred for 2 hours and concentrated in vacuo. The residue was triturated with cold hexanes to give a white solid which was collected by filtration to give 19.12 g of a white solid, mp 62°-63° C.

Provenance & Evidence