Hydrochloric Acid → 4-Ethylhexa-2,4-dienoic acid

Participants

Reaction Steps

To a solution of 20.0 kg (119 mol) of ethyl (E,E)-4-ethyl-2,4-hexadienoate in 15 l of methanol is added a solution of 6.0 kg (150 mol) of sodium hydroxide in 60 l of water. The mixture is heated at 50°-55° C. for 1 hour and then cooled to 20°~25° C., poured into a 8%-hydrochloric acid solution at same temperature. The precipitate formed is collected by filtration, washed with 200 l of water and dried in vacuo overnight to give 16.2 kg of (E,E)-4-ethyl-2,4-hexadienoic acid (Yield 97.4%).

Provenance & Evidence