Sulfuric Acid → HCID 19788877, compound
Reaction equation
[CH3:1][CH:2]([C:7]([F:10])([F:9])[CH3:8])[C:3]([F:6])([F:5])[F:4].S(=O)(=O)(O)[OH:12]>O>[CH3:1][C:2]([OH:12])([C:7]([F:10])([F:9])[CH3:8])[C:3]([F:6])([F:5])[F:4]Participants
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
As another example, 2-methyl-1,1,1,3,3-pentafluoro-2-butanol may be prepared by fluorinating commercially available 2-methyl-1-buten-3-yne to form 2-methyl-1,2,3,4-tetrafluoro-1-butene which may then be reacted with hydrogen fluoride to form 2-methyl-1,2,3,3,4-pentafluorobutane. The 2-methyl-1,2,3,3,4-pentafluorobutane may then be dehalogenated to form 3-methyl-2,3,4-trifluoro-1-butene which may then be reacted with hydrogen fluoride to form 2-methyl-1,2,3,3-tetrafluorobutane. The 2-methyl-1,2,3,3-tetrafluorobutane may then be dehalogenated to form 2-methyl-1,3,3-trifluoro-1-butene which may then be fluorinated to form 2-methyl-1,1,2,3,3-pentafluorobutane. The 2-methyl-1,1,2,3,3-pentafluorobutane may then be dehydrohalogenated to form 2-methyl-1,1,3,3-tetrafluoro-1-butene which may then be reacted with hydrogen fluoride to form 2-methyl-1,1,1,3,3-pentafluorobutane. The 2-methyl-1,1,1,3,3-pentafluorobutane may then be dehydrogenated and then reacted with sulfuric acid and water to form 2-methyl-1,1,1,3,3-pentafluoro-2-butanol.
Sources & evidence
- ORD record
- ord-b53c51ae55204fb4b035b9c91b911907
- Source dataset
- uspto-grants-1993_10
- Patent number
- US05254755
Reaction notes
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