1,1,1,3,3-Pentachloropropanone → Pentafluoroacetone

HRID 1656838Notes

Reaction equation

HRID 1656838 reaction equation
[F:1][CH:2]([F:12])[C:3]([OH:11])(C(F)F)[C:4]([F:7])([F:6])[F:5].ClC(Cl)(Cl)C(=O)C(Cl)Cl>>[F:5][C:4]([F:7])([F:6])[C:3](=[O:11])[CH:2]([F:12])[F:1]

Participants

3

Reactant 2

HCID 156731,1,1,3,3-PentachloropropanoneHCID 19788901HCID 19788901, compound

Product 1

HCID 67939Pentafluoroacetone

Procedure

As another preparation example, 2-difluoromethyl-1,1,1,3,3-pentafluoro-2-propanol may be prepared by fluorinating commercially available 1,1,1,3,3-pentachloro-2-propanone to form 1,1,1,3,3-pentafluoro-2-propanone which may then be reacted with CF2 carbene to form 2-difluoromethyl-1,1,3,3,3-tetrafluoro-1-propene. The 2-difluoromethyl-1,1,3,3,3-tetrafluoro-1-propene may then be reacted with sulfuric acid and then water to form 2-difluoromethyl-1,1,1,3,3-pentafluoro-2-propanol.

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-1755bc959e524787ae4d37551f896377
Source dataset
uspto-grants-1993_10
Patent number
US05254755

Reaction notes

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