Sulfuric Acid → HCID 19788851, compound
Reaction equation
[F:1][CH:2]([F:10])[CH:3]([CH:7]([F:9])[F:8])[CH:4]([F:6])[F:5].S(=O)(=O)(O)[OH:12]>O>[F:1][CH:2]([F:10])[C:3]([OH:12])([CH:7]([F:9])[F:8])[CH:4]([F:6])[F:5]Participants
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
As another example, the 2-difluoromethyl-1,1,3,3-tetrafluoro-2-propanol may be prepared by fluorinating commercially available 1,1,3-trichloro-2-propanone to form 1,1,3-trifluoro-2-propanone which may then be reacted with CF2 carbene to form 2-fluoromethyl-1,1,3,3-tetrafluoro-1-propene. The 2-fluoromethyl-1,1,3,3-tetrafluoro-1-propene may then be hydrogenated to form 2-fluoromethyl-1,1,3,3-tetrafluoropropane. The 2-fluoromethyl-1,1,3,3-tetrafluoropropane may then be dehydrogenated to form 2-difluoromethyl-1,3,3-trifluoro-1-propene which may then be reacted with hydrogen fluoride to form 2-difluoromethyl-1,1,3,3-tetrafluoropropane. The 2-difluoromethyl-1,1,3,3-tetrafluoropropane may then be dehydrogenated and then reacted with sulfuric acid and then water to form 2-difluoromethyl-1,1,3,3-tetrafluoro-2-propanol.
Sources & evidence
- ORD record
- ord-41273238070e4283b508e78276306cab
- Source dataset
- uspto-grants-1993_10
- Patent number
- US05254755
Reaction notes
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