Fluorobenzene → 4-Bromo-2-fluoro-1,1'-biphenyl

Participants

Reaction Steps

Using methodology generally similar to the above examples, 1.22 g of phenylboronic acid in about 5 ml of ethanol, 3 g of 2-fluoro-4-bromoiodobenzene, 20 g of fluorobenzene, 0.2 g of 5% Pd on carbon catalyst, and 10 ml of 2 molar Na2CO3 were combined and stirred rapidly (without a nitrogen purge) at 25° C. for 65 hours. The desired 2-fluoro-4-bromobiphenyl was produced in about 10% yield with only partial conversion of the starting materials, considerable byproduct formation, but no observed terphenyl formation.

Provenance & Evidence