Succinic anhydride → 4-(4-heptylphenyl)-4-oxobutanoic acid

HRID 1656877Notes

Reaction equation

[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.C(OC1C=CC=CC=1)CCCCCC.[CH2:22]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>>[CH2:22]([C:29]1[CH:30]=[CH:31][C:32]([C:1]([CH2:2][CH2:3][C:4]([OH:6])=[O:5])=[O:7])=[CH:33][CH:34]=1)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Participants

Reactant 3

HCID 7922Succinic anhydride

HCID 14115Heptylbenzene

HCID 11392287Benzene, (heptyloxy)-

Product 1

HCID 28014724-(4-heptylphenyl)-4-oxobutanoic acidYield 70.2%

Procedure

The first step of Example 1 was repeated except that succinic anhydride (62.4 g) was replaced by 68.1 g thereof and heptyloxybenzene (100 g) was replaced by heptylbenzene (100 g), to obtain 3-(4-heptylbenzoyl)propionic acid (110 g). m.p.: 101.0°-103.5° C.

Sources & evidence

ORD record: ord-5a11575de4b74c8e91638741b5a3de26
Source dataset: uspto-grants-1993_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05256330

Reaction notes

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