Hydrochloric Acid → HCID 19786475, compound

Participants

Reaction Conditions

Reaction Steps

The 1-(ethoxycarbonyl)semicarbazide VII (10.28 g, 0.0385 mol) was added to a solution of potassium hydroxide (4.96 g, 0.0769 mol) in water (105 mL) and the suspension was stirred and heated in an oil bath at 95° C. (oil bath temp.) for one hour. The yellow mixture was cooled to 25° C. and filtered. The filtrate was further cooled in an ice bath and neutralized by the slow addition of 6.72 ml (0.0807 mol) of conc. HCl. After 15 min. a white precipitate of VI was collected by filtration, washed with water and dried to constant weight. Yield: 6.56 g (77%); mp 187°-189° C. 1H NMR (DMSO-d6,): δ=10.15 (s, 2H, equivalent NH's).

Provenance & Evidence