HCID 19100862, compound → HCID 19100909, compound

HRID 1656916Notes

Reaction equation

HRID 1656916 reaction equation
[CH3:1]N(C)C1NC(=O)C(CCO)=C(C)N=1.[Cl:15][CH2:16][CH2:17][C:18]1[C:19](=[O:29])[N:20]([CH3:28])[C:21]([N:25](C)[CH3:26])=[N:22][C:23]=1[CH3:24].ClCCC1C(=O)N(CCC)C(N(C)C)=NC=1C.Cl.ClCCC1C(=O)N(CC)C(N(C)C)=NC=1C>>[Cl:15][CH2:16][CH2:17][C:18]1[C:19](=[O:29])[N:20]([CH3:28])[C:21]([NH:25][CH2:26][CH3:1])=[N:22][C:23]=1[CH3:24]

Participants

5

Reactant 4

HCID 19100862HCID 19100862, compoundHCID 19100924HCID 19100924, compoundHCID 19100930HCID 19100930, compoundHCID 135736976HCID 135736976, compound

Product 1

HCID 19100909HCID 19100909, compound

Procedure

and further, following the same procedures 2-dimethylamino-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone (Coll. Czech. Chem. Commun., 32, 1582, 1967) was converted into 5-(2-chloroethyl)-2-(dimethylamino)-3,6-dimethyl-4(3H)-pyrimidinone (interm. 32); 5-(2-chloroethyl)-2-(dimethylamino)-6-methyl-3-propyl-4(3H)-pyrimidinone (interm. 33); and 5-(2-chloroethyl)-2-(dimethylamino)-3-ethyl-6-methyl-4(3H)-pyrimidinone monohydrochloride (interm. 34).

Sources & evidence

ORD record
ord-cff1cfb2c14049fa8cf57331463a5755
Source dataset
uspto-grants-1993_10
Patent number
US05256659

Reaction notes

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